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And growth hormone is closely tied to: Collagen production Skin thickness Elasticity Muscle tone As we age, GH levels naturally decline

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Shear stress-regulated metabolic reprogramming of ecs in aging and atherosclerosis ECs are constantly exposed to blood flow-derived shear stress [192], which critically determines their metabolic phenotype and function

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For example, mean synaptic density peaks at 8 mo of age in the visual cortex and at 3.6 yr of age in the auditory and prefrontal cortex, after which synapse elimination eventually results in adult levels of synaptic density during late adolescence (Huttenlocher & Dabholkar, 1997)